Diaba Free is administered via topical application to the palms and soles, adhering to the ancient Ayurvedic practice of padabhyanga, as described in Charak Samhita, Sutra Sthana, chapter 5, shlokas 90-92. This practice is based on the premise that the soles of the feet serve as critical nodes for systemic therapeutic interventions due to their extensive vascular and nerve connections.

• 1

  Ayurvedic Therapy and Mechanotransduction (Padabhyanga)

  Diaba Free is administered via topical application to the palms and soles, adhering to the ancient Ayurvedic practice of padabhyanga, as described in Charak Samhita, Sutra Sthana, chapter 5, shlokas 90-92. This practice is based on the premise that the soles of the feet serve as critical nodes for systemic therapeutic interventions due to their extensive vascular and nerve connections.

  "Padabhyanga involves massaging the feet to promote relaxation and improve systemic health by targeting key points rich in nerve endings and blood vessels" (Charak Samhita, Sutra Sthana, 5.90-92).

• 2

  Mechanotransduction and Hemodynamics

  The massage-induced mechanotransduction activates mechanoreceptors and endothelial cells, promoting vasodilation and enhancing peripheral blood circulation. This improved hemodynamic flow supports nutrient and drug delivery to distal tissues.

  "Mechanotransduction induced by massage stimulates endothelial cells, leading to vasodilation and improved peripheral blood flow, which enhances nutrient delivery to tissues" (Thijssen et al., 2010, p. H1326).

• 3

  Pharmacodynamic Activity of Ayurvedic Ingredients

  The Ayurvedic formulation within Diaba Free comprises bioactive phytochemicals known for their antihyperglycemic properties. These compounds modulate insulin secretion, glucose uptake, and glycogen synthesis pathways to regulate blood glucose levels.

  "Certain Ayurvedic herbs possess antihyperglycemic properties, influencing insulin secretion and glucose metabolism, thereby helping to manage blood sugar levels" (Pandey et al., 2013, p. 3).

Diaba Free leverages a sophisticated transdermal drug delivery system, a method corroborated by Ayurvedic abhyanga techniques, to facilitate systemic absorption of therapeutic agents through the skin.

• 1

  Transdermal Drug Delivery System (TDDS)

  Diaba Free leverages a sophisticated transdermal drug delivery system, a method corroborated by Ayurvedic abhyanga techniques, to facilitate systemic absorption of therapeutic agents through the skin.

  "Transdermal drug delivery systems enable the efficient absorption of active compounds through the skin, ensuring sustained therapeutic levels in the bloodstream" (Prausnitz & Langer, 2008, p. 1262).

• 2

  Alleviation of Diabetic Neuropathy Symptoms

  Regular hastha and pada-abhyanga (hand and foot massage) mitigates neuropathic symptoms such as paresthesia, dysesthesia, and neuropathic pain. This is achieved through improved microcirculation and the activation of cutaneous nociceptors, which modulate pain signaling pathways.

  "Massage improves microcirculation and stimulates nociceptors, which helps in alleviating neuropathic pain and discomfort associated with diabetic neuropathy" (Boulton et al., 2005, p. 960).

• 3

  Cutaneous Absorption and Systemic Distribution

  The transdermal absorption of Diaba Free's herbal constituents involves the diffusion of molecules across the stratum corneum, followed by permeation through the epidermal and dermal layers. The bioactive compounds subsequently enter the systemic circulation, ensuring therapeutic concentrations are maintained in the bloodstream.

  "Transdermal absorption involves the diffusion of active molecules through the skin layers into the systemic circulation, maintaining effective therapeutic levels" (Wokovich et al., 2006, p. 3).

• 4

  Biochemical Modulation of Glycemic Control

  Upon systemic absorption, the herbal bioactives exert their effects on key metabolic pathways. This includes modulation of the pancreatic beta-cell function, inhibition of alpha-glucosidase and alpha-amylase enzymes, and enhancement of glucose transporter activity (GLUT-4), collectively contributing to reduced blood glucose levels.

  "Phytochemicals in Ayurvedic medicine modulate pancreatic beta-cell activity and inhibit carbohydrate-digesting enzymes, aiding in glycemic control" (Tiwari & Madhusudana, 2002, p. 33).